population: a review of previous studies]]> arterial thrombosis, as well as a risk of adverse pregnancy outcomes. Gene variants that are the most
commonly associated with inherited thrombophilia are F5 mutation 1691G>A (Factor V Leiden), F2
20210G>A (prothrombin mutation), MTHFR 677C>T, and PAI-1 variant 4G/5G. This paper aims to
review currently available literature on the prevalence of heritable thrombophilia genetic markers
and their association with thromboembolic events in Bosnia and Herzegovina. PubMed and PubMed
Central databases of the National Center for Biotechnology Information (NCBI) and ResearchGate
were searched to identify the most relevant studies. The results of the previously published studies
show discrepancies when it comes to reported findings, thus implying that further research on this
topic is necessary. It is suggested that new studies include greater sample size in order to confirm the
correlation between the studied variants and conditions associated with heritable thrombophilia in
the Bosnian-Herzegovinian population and to advance the understanding of these variants.]]>